The game takes place in 1481. You play as John, a young man who has been publicly humiliated and lives on the streets. Suspected of witchcraft, he is tortured in a Spanish Inquisition prison. He later undergoes an alchemical transformation that renders him immortal. But things don't go as planned. After each resurrection, John loses all of his memory. 500 years later, in the present day, John lives in Paris with Pauline, his immortal wife. Together, they search for the artifact needed to reenact the ritual.